A stochastic model of coupled enzymatic degradation

5 May 2010

Ruth Williams
Department of Mathematics and Biocircuits Institute
UC San Diego


A major challenge for systems biology is to deduce the molecular interactions that underlie correlations observed between concentrations of different intracellular molecules. While direct explanations such as coupled transcription/translation or direct protein-protein interactions are often considered, potential indirect sources of coupling have received much less attention. In this talk, I will report on experiments and a related stochastic model that show how correlations can arise generically from a post-translational coupling mechanism involving the processing of multiple protein species by a common enzyme.

This talk is baed on joint work with Natalie Cookson, Jeff Hasty, Will Mather, Octavio Mondragon-Palomino and Lev Tsimring