27 October 2006
Martin Meier-Schellersheim
Laboratory of Immunology
NIAID, NIH
The deep scepticism that most experimental biologists have towards computational modeling in biology is rooted in the fact that computational models are frequently overly simplified caricatures of the biological processes they are supposed to represent. Two main factors account for those simplifications:
M. Meier-Schellersheim, X. Xu, B. Angermann, E.J. Kunkel, T. Jin & R.N. Germain, "Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method", PLOS Comp Biol, 2:710-24 2006. PubMed