UG research student |
Kyle worked on modelling calcium oscillations for Biochemical Sciences 91R and then studied cell-to-cell variation in EGF signalling for his Senior Honours Thesis, supervised by Yanging Xu. Kyle is currently at medical school at Northwestern. last updated on 21 December 2008 |
Summer student |
Felix wrote a generic module for receptor endocytosis, recycling and degradation in little b last updated on 19 May 2006 |
Postdoctoral Fellow |
My dissertation work was in mathematics, studying the impact of positive and negative feedback on the behavior of dynamical systems in an abstract context. I have applied this work to models of biochemical reactions and reaction diffusion systems, and I have done some modeling of retinal interneurons. In Jeremy's lab, I am developing generic modules for biochemical reactions in little b and will use them to study signal transduction pathways associated with EGF receptors. I am currently an Assistant Professor at UC Irvine. My website is here. last updated on 28 October 2009 |
UG research student |
Mark did a Senior Honours Thesis on "Differential and graphical approaches to multistability in chemical reaction networks"; available at arxiv.org/abs/0709.0125. It was awarded a Department of Mathematics Friends' Prize and a Harvard University Thomas T Hoopes Prize. last updated on 18 January 2008 |
Senior Research Scientist |
Prior to joining the Systems Biology Department, I spent several years at Millennium Pharmaceuticals during the heyday of genomics developing technology and leading efforts to integrate and share structured scientific knowledge. During that time, I had the opportunity to spend a year at the Harvard Center for Genomics Research to understand how systems theory could be applied to problems in drug discovery. One outstanding problem was how to simplify the process of building reliable models. I imagined a tool that would enable a modeler to "mix together" predefined, trusted components. These would automatically wire themselves together - in analogy to how a biochemist reconstitutes a system by mixing proteins in a test tube. I proposed a computational framework based on this idea, and this evolved into little b, a LISP-based programming language designed for building modular, shareable models. My formal training has been in cell biology and biochemistry, though I've had a long interest in computing. I got my start in science with Dan Jay, then a professor at the Harvard BioLabs. We created microCALI, a microscope-based version of the chromophore-assisted laser inactivation technology which he pioneered, and used it to investigate the role of molecules in nerve cell growth. I did my Ph.D. at UCSF with Tim Mitchison, developing photoactivation and photobleaching technologies to visualize cytoskeletal dynamics involved in: neuronal tip movement, mitosis, and cell division orientation. last updated on 24 February 2006 |
UG research student |
Raj worked on steady-state invariants for multisite phosphorylation for Physics 90R and is first author on the paper that emerged from that. He also worked with German Enciso on EGF receptor dimerisation. He is currently a graduate student in the Harvard-MIT HST programme. last updated on 28 October 2009 |
UG research student |
I am a 4th year student from Anna University in Chennai, India doing my senior thesis in Bioengineering. Switching between the fundamentals of Mathematics, Biochemistry and Computers, I am studying the degree to which Flux Balance Analysis can correctly predict the internal fluxes in yeast. Also, I am trying to implement different biomass equations and additional constraints to improve the reliability and prediction capability of existing networks available in the literature. I will be pursuing my graduate studies at the University of California, Irvine. My website is here last updated on 4 May 2009 |
Research Assistant |
Matt is currently a graduate student in the Harvard Biophysics programme. He worked on several experimental, computational and theoretical projects, was co-author of one paper on little b and first author on two others on multisite phosphorylation. last updated on 28 October 2009 |
Summer student |
Ben has worked on various aspects of the little b system. He is studying computer science at Columbia. last updated on 24 February 2006 |
