Network approaches to hereditary diseases and the organization of eukaryotic phosphorylation systems

4 March 2016

Esti Yeger-Lotem
Department of Clinical Biochemistry & Pharmacology
Ben-Gurion University of the Negev, Israel


A longstanding puzzle in human genetics is what causes many hereditary diseases to manifest clinically in specific tissues. We approach this fundamental question using comparative network analyses and I will describe some factors that may contribute to this phenomenon. In the second part of the talk I will describe our analysis of the balance between protein kinases and phosphatases. By analyzing a large variety of 'omics' datasets, we find that while kinases and phosphatases regulate the same set of target proteins, they employ different and compensatory strategies that are conserved across diverse eukaryotes.

current theory lunch schedule