9 April 2010
Concord Biomedical Sciences and Emerging Technologies
Drug discovery programs typically focus on optimizing pharmacological potency. Yet, there is an increasing appreciation that receptor binding and pharmacological potencies are poor predictors of in-vivo drug effects in solid tissue [1,2]. Thus, drug delivery to tumors, muscle tissue and the walls of arteries all emphasize the fundamental need for a deep understanding of extracellular transport, cell pharmacokinetics, not only pharmacology. Mathematical modeling offers a convenient framework for elucidating and integrating all these processes. In this talk, I will review how mathematical modeling is helping us elucidate the physiological barriers shaping the efficacy of local therapies aimed at inducing angiogenesis  or at inhibiting tissue hyperplasia .
current theory lunch schedule