Reduce, reuse, recycle: the dynamics of regulatory information usage in development

6 Dec 2013

Jason Lieb
Department of Molecular Biology
Lewis Sigler Institute for Integrative Genomics
Princeton University


Genomic technologies have opened a window into how regulatory information is encoded in DNA, and how access to that information is controlled. I will discuss these issues on three scales (1) How continual competition between nucleosomes and transcription factors may act as a clutch for transcriptional regulation; (2) How the nuclear envelope acts as an organizer for regulatory information; and (3) surprising re-use of the same subset of DNA regulatory elements to control the development of wings, legs, and halteres in Drosophila. The floor will be open for a discussion of how all of these tie together, and any other related topics.

current theory lunch schedule