4 October 2013
Alexander Hoffmann
Signalling Systems Laboratory, San Diego Center for Systems Biology and Department of Chemistry and Biochemistry, UC San Diego
Computational Biosciences Institute and Department of Microbiology, Immunology and Molecular Genetics, UC Los Angeles
Cellular responses to stress agents such as inflammatory cytokines or pathogens involve transcription factors that exhibit complex dynamics. I will discuss our recent studies on whether these dynamics represent a signaling code that may specify cellular gene expression responses, and to what extent such a code may be harnessed to achieve greater pharmacological specificity when targeting pleiotropic signaling hubs.