6 March 2015
Suzanne Gaudet
Dana Farber Cancer Institute and
Department of Genetics, Harvard Medical School
Diagrams of signal transduction networks convey the idea of time via the description of a sequence of events leading to a cellular response. Yet time matters in many different ways in the process of signal transduction. Drawing from our work on TNF-induced transcription and cell fate decisions, I will discuss what signaling dynamics have revealed to us about the underlying signaling network and a few thoughts about when duration of a cytokine treatment may or may not matter.