23 Mar 2012
Department of Cell and Developmental Biology
University of Michigan Medical School
A handful of ancient cell-cell signaling pathways, whose function is purely informational, are major determinants of developmental pattern, organogenesis, stem cell fates, and cancer (which can be considered a disease of misinformation). These signal transduction pathways, including Hedgehog, Wnt, Notch, and RTK/Ras/MAPK, act primarily by regulating specific transcription factors (TFs), which bind to specific DNA sequences within enhancers of pathway target genes and control their expression.
Our lab tries to understand the cell's response to signaling by dissecting and decoding the cis-regulatory DNA of signal-regulated enhancers. In this chalk talk, several questions will be addressed (but probably not answered):
current theory lunch schedule