1 May 2009
Adam Arkin
Department of Bioengineering
UC Berkeley
We are investigating approaches that link phylogenetic and comparative functional genomics analyses to physical chemical dynamics of cellular networks and evolutionary game theory to create a theory of the architecture of cellular networks. We have applied the approach to understanding the evolution and dynamics of viral gene expression in HIV and bacterial signaling pathways particularly in Bacillus subtilis and demonstrated the functional role of noise and memory in enhancing the fitness of these systems under stress. We will also show how a few derived principles for design have application in synthetic biology applications.