Network motifs and their biological functions

Uri Alon


Network motifs are recurring circuit elements in biological networks. In this chalk-talk, we will discuss the mathematical and experimental analysis of the information processing functions of network motifs. We will analyze several design-principles that cells use for speeding transcription network response-times. We will also discuss the selection of network motifs from an evolutionary perspective.


S. Mangan and U. Alon, "Structure and function of the feed-forward loop network motif", PNAS, 100:11980-5, 2003. PDF.

N. Rosenfeld, M. Elowitz and U. Alon, "Negative autoregulation speeds the response times of transcription networks", J. Mol. Biol., 323:785-93, 2002. PDF.

S. Managan, A. Zaslaver and U. Alon, "The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks", J. Mol. Biol., 334:197-204, 2003. PDF.